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The goal of this proposal is to find keys to re-open plasticity in hardwired circuits of sensori-motor function. Clues are taken from the condensation of glycan-rich peri-neuronal and astrocytic nets in the mature central nervous system.  Age-related changes in the glycan components of perineuronal nets invite the search for plasticity-inducing factors harboured in the net environment.  Examples will be drawn from studies in rodents with respect to developmental maturation of the central vestibular pathway for graviception and spatial navigation as well as responses to sensory loss in adults.  Findings will open opportunities to target the glycan domains of the nets as a novel strategy for reinstating circuit plasticity by resetting excitatory/inhibitory balance according to experience in otherwise hardwired circuits.
  • DAYS
Key Dates

Deadline for PTA Application:
June 20, 2018

Deadline for Young Investigator Colloquium submission:
February 28, 2018

Deadline for Abstract submission

June 30, 2018

Conference Date:
August 27-29, 2018